Another angiogenesis-independent role for VEGF: SDF1-dependent cardiac repair via cardiac stem cells
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چکیده
منابع مشابه
Another angiogenesis-independent role for VEGF: SDF1-dependent cardiac repair via cardiac stem cells.
Mounting evidence indicates that the vascular endothelial growth factor gene (encoding the secreted growth factor VEGF) is one of those few truly essential genes in the mammalian genome. Indeed, genetic haploinsufficiency of one VEGF allele is incompatible with life and birth due to severe embryonic defects in the conversion of single endothelial cells into a network of blood vessels, thereby e...
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The skeletal muscle is endowed with an impressive ability to regenerate after injury, and this ability is coupled to paracrine production of many trophic factors possessing cardiovascular benefits. Taking advantage of this humoral capacity of the muscle, we recently demonstrated an extracardiac therapeutic regimen based on intramuscular delivery of VEGF-A(165) for repair of the failing hamster ...
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Objective(s):Although previous studies have confirmed the beneficial effects of human umbilical cord matrix stem cell (hUCM) transplantation post myocardial infarction (MI), but this stem cell resource has no potential to induce angiogenesis. In order to achieve the process of angiogenesis and cardiomyocyte regeneration, two required factors for cardiac repair agents were examined namely; hUCM ...
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Discovery of tissue specific stem cells capable of forming cardiac cell types has revolutionized cardiac medicine. Not long ago, cardiac tissue regeneration was considered an impossible task. The last ten years however has seen an explosion of cell based therapeutic approaches stimulating cardiac regeneration and in the process augmenting function in the heart following injury. Encouraging prec...
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Cardiovascular disease is a major cause of morbidity and mortality throughout the world. Most cardiovascular diseases, such as ischemic heart disease and cardiomyopathy, are associated with loss of functional cardiomyocytes. Unfortunately, the heart has a limited regenerative capacity and is not able to replace these cardiomyocytes once lost. In recent years, stem cells have been put forward as...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2011
ISSN: 0008-6363
DOI: 10.1093/cvr/cvr184